IIT Roorkee Researchers have discovered a new antibacterial tiny molecule (IITR00693.) It could benefit the fight against drug-resistant infections. This could open new research routes on treatment choices for soft and skin tissue illnesses.
The research was directed by Prof Ranjana Pathania, Department of Biosciences and Bioengineering. Mahak Saini, as well as Amit Gaurav of the same institute. Also includes Ashish Kothari as well as Balram Ji Omar of AIIMS, and Rishikesh from Assam University.
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“The molecule, found after a rigid screening procedure. The screening had shown powerful antibacterial activity. Against a vast range of Gram-positive as well as Gram-negative bacteria. It had some of the vastly problematic drug-resistant strains. With numerous bacterial infections becoming immune to existing cures. The discovery of this unique molecule offers the possibility for more practical and targeted therapies. IITR00693 functions like a dual sword. It attacks the most tenacious bacteria. This also prevents the emergence of resistance. It ensures that it stays influential for generations to come,” IIT Roorkee said in a press dismissal.
Speaking about the discovery. Prof K K Pant, Director, of IIT Roorkee Researchers, said, “We are now functioning to further evolve the molecule. A viable therapeutic agent that can be experimented with in clinical trials. This is a crucial step in the growth of new antibiotics. It will permit the evaluation of the molecule’s safety, efficacy, and potential side impacts in soft and skin tissue infections.”
Lead researcher Ranjana Pathania said we sought to determine a small molecule that can potentiate nowadays used antibiotics. IITR00693, a novel antibacterial small molecule. It potentiates the antibacterial action of polymyxin B against Staphylococcus aureus as well as Pseudomonas aeruginosa. Herein, we examined in detail the mode of action of this interchange. The molecule’s ability to fight soft-tissue infections induced by S. aureus and P.aeruginosa.”
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